Novel Biomarkers in the Continuum of Breast Cancer


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Patricia A. Ganz , MD was awarded a new grant to test promising interventions to help young women with breast cancer cope with ongoing psychosocial stress and symptoms related to their diagnosis and treatment. This project builds on Dr.

Breast Cancer

While grantmaking is our primary function in our mission to end breast cancer, it is not the only way BCRF advances science. In , BCRF announced a new partnership with Nature , the internationally renowned scientific publisher, and the launch of npj Breast Cancer , an open-access research journal, with Drs.

Larry Norton and Clifford Hudis serving as editors-in-chief. To date, three volumes are near completion or in production, with members of the Scientific Advisory Board spearheading the volumes. Vered Stearns , is nearing completion. A third volume on genetics to be edited by Dr. Judy Garber has just been announced.

Collaboration is a hallmark of all our research activities, from the Evelyn H.

BCRF has also played a leadership role in convening experts to discuss new strategies to address persistent challenges in the treatment of breast cancer. Also in October, BCRF organized and hosted a two-day meeting to enhance efforts to reduce breast cancer disparities. Spearheaded by Scientific Advisory Board member Dr.

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Patricia Ganz, the meeting convened experts in disparities and health outcomes research, epidemiology, psychosocial and behavioral sciences, research oncologists and representatives from the patient community. We've been fortunate in being able to identify the most promising and innovative projects and investigators early and therefore help support them in making these advances.

From paying tribute to a loved one to workplace giving, there are a variety of ways to support research. Skip to main content. Peter Greenwald and Vered Stearns. BCRF News. Science News.

Bibliographic Information

Other checkpoint inhibitors are being actively investigated [ 82 ]. In breast cancer, preliminary results of phase I trials of anti-PD-L1 in metastatic breast cancer have shown encouraging results [ 83 ].


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It needs to be investigated which is the preferred delivery of immune therapy in breast cancer, as single agents or together with chemotherapy. Immunotherapy represents a promising treatment modality that warrants further research in breast cancer, especially in TNBC for which effective treatments are lacking. In addition, biomarkers predicting benefit from immunotherapy need to be identified. Although PD-L1 expression was used for eligibility in breast cancer trials thus far, its predictive value for the benefit from immunotherapy is unknown.

Other immune parameters such as TILs may be candidate biomarkers [ 35 ]. The potential synergies between immunotherapy and existent therapies used in breast cancer should be explored. Close to 50 trials in immunotherapy are now open to breast cancer patients, many of which combine it with HER2-targeted therapy, chemotherapy, or endocrine therapy. Emerging information suggests that current immunotherapy approaches may be more effective in tumors with a higher mutational load.

Strategies to increase the mutational load of certain tumors may actually expand the possibilities of immunotherapy.

Breast Cancer Treatment at the Continuum Cancer Centers of New York- Dr. Paula Klein

In addition, new imaging methodologies to correctly assess response to these agents are needed. Due to their extremely high cost, it is of paramount importance to assess the true value of this approach as well as to identify patients who will derive benefit from it. The improvement in breast cancer prognosis in the last decades has resulted in an increasing number of survivors and a growing issue of survivorship. However, it is acknowledged that evidence is lacking to warrant strong, evidence-based recommendations on many issues of survivorship care [ 85 ].

Furthermore, there is great heterogeneity and difficulty in predicting who will develop both medical and psychosocial long-term and late effects after treatment. Improved rigorous databases and cohorts should be developed and supported to inform medical outcomes.

Novel Biomarkers in the Continuum of Breast Cancer

Several QoL assessment tools exist, but few evaluate all the different aspects of QoL—psychological, social, physical and spiritual—[ 86 ], and few have been specifically validated in the breast cancer population [ 87 ]. In addition, due to lack of clinical interpretation or difficulty in application, QoL results are seldom applied in clinical practice [ 88 , 89 ]. To fill this gap, improved assessment or interpretation tools need to be developed. Guidelines to aid interpretation of QoL results may help ensure that available QoL results are actually used in clinical decision-making [ 90 , 91 ].

In addition, as patients are discharged to primary care for follow-up and the survivorship period is prolonged, there is a need for better follow-up tools and guidance, for both patients and primary care physicians. Distance and online follow-up tools may provide solutions [ 92—94 ], and their development and use should be strongly encouraged. Long-term follow-up is crucial since breast cancer has a very prolonged natural history. It does, however, pose important logistical issues and requires the implementation of new communication technologies allowing patients to directly provide their follow-up.

Research into all aspects of optimal patient management and survivorship is important worldwide, including low- and middle-income countries [ 95 , 96 ]. A major unmet need is the development of a specific QoL tool for advanced breast cancer patients to correctly ascertain the impact of new therapies. Furthermore, some advanced breast cancer patients, especially the HER2-positive subtype, can now live for 8 or 9 years and have specific survivorship issues that need close attention. Of paramount importance are issues of availability and access to care, high-quality guidelines and their implementation as well as adequate ongoing education and training of all oncologists.

These are issues common to the management of all malignancies and will not be discussed here.

The research priorities identified by the panel of experts reflect the evolution of breast cancer management in the last few decades and emerging medical needs, with increasing importance placed in the management of metastatic breast cancer, individually tailored treatment, and survivorship. We acknowledge Vanessa Marchesi and Yuki Takahashi for coordinating the project and editing the article. PAF has received travel support from Roche and Pfizer and served on an advisory board for Pfizer uncompensated. Oxford University Press is a department of the University of Oxford.

It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Sign In.

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Advanced Search. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents. Editor's Choice. Research needs in breast cancer F. Oxford Academic.

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Google Scholar. El Saghir. Cite Citation. Permissions Icon Permissions. Table 1. Summary of research needs in breast cancer identified by the panel and suggested actions. Defining research priorities without biases: what is the optimal process? Search ADS. International variation in female breast cancer incidence and mortality rates. A systematic assessment of benefits and risks to guide breast cancer screening decisions.

American Society of Clinical Oncology clinical practice guideline: update on adjuvant endocrine therapy for women with hormone receptor-positive breast cancer. Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among , women in randomised trials. Effect of radiotherapy after breast-conserving surgery on year recurrence and year breast cancer death: meta-analysis of individual patient data for 10, women in 17 randomised trials.

Effect of radiotherapy after mastectomy and axillary surgery on year recurrence and year breast cancer mortality: meta-analysis of individual patient data for women in 22 randomised trials. Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about , women in US SEER cancer registries. SWOG S a phase III, randomized clinical trial of standard adjuvant endocrine therapy with or without chemotherapy in patients with one to three positive nodes, hormone receptor HR -positive, and HER2-negative breast cancer with recurrence score RS of 25 or less.

West German Study Group Phase III PlanB Trial: first prospective outcome data for the gene recurrence score assay and concordance of prognostic markers by central and local pathology assessment. Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer.

Biomarkers of radiation exposure: can they predict normal tissue radiosensitivity? Proteomics discovery of radioresistant cancer biomarkers for radiotherapy. Adjuvant endocrine therapy for women with hormone receptor-positive breast cancer: american society of clinical oncology clinical practice guideline focused update. A randomized trial MA. Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: final results of the FinHer Trial.

Optimal adjuvant treatment for patients with HER2-positive breast cancer in Management of locally advanced and metastatic breast cancer: guidelines, infrastructures and low resource settings.


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Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis. Clinical relevance of host immunity in breast cancer: from TILs to the clinic. PARP inhibitors in the management of breast cancer: current data and future prospects. First international consensus guidelines for breast cancer in young women BCY1. Adjuvant exemestane with ovarian suppression in premenopausal breast cancer.

Elucidating prognosis and biology of breast cancer arising in young women using gene expression profiling. Impact of fertility preservation counseling and treatment on psychological outcomes among women with cancer: a systematic review. The genomic and transcriptomic architecture of 2, breast tumours reveals novel subgroups. Clinical trials of precision medicine through molecular profiling: focus on breast cancer.

Novel Biomarkers in the Continuum of Breast Cancer Novel Biomarkers in the Continuum of Breast Cancer
Novel Biomarkers in the Continuum of Breast Cancer Novel Biomarkers in the Continuum of Breast Cancer
Novel Biomarkers in the Continuum of Breast Cancer Novel Biomarkers in the Continuum of Breast Cancer
Novel Biomarkers in the Continuum of Breast Cancer Novel Biomarkers in the Continuum of Breast Cancer
Novel Biomarkers in the Continuum of Breast Cancer Novel Biomarkers in the Continuum of Breast Cancer
Novel Biomarkers in the Continuum of Breast Cancer Novel Biomarkers in the Continuum of Breast Cancer

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